Effect of double mutations T790M/L858R on conformation and drug-resistant mechanism of epidermal growth factor receptor explored by molecular dynamics simulations-Reference-Cited by-同舟云学术

Effect of double mutations T790M/L858R on conformation and drug-resistant mechanism of epidermal growth factor receptor explored by molecular dynamics simulations

Published:2018 Issue:70 Volume:8 Page:39797-39810
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Yan Fangfang¹²³⁴,Liu Xinguo¹²³⁴^ORCID,Zhang Shaolong¹²³⁴,Su Jing¹²³⁴,Zhang Qinggang¹²³⁴,Chen Jianzhong⁵⁶³⁴^ORCID

Affiliation:

1. School of Physics and Electronics

2. Shandong Normal University

3. Jinan

4. China

5. School of Science

6. Shandong Jiaotong University

Abstract

The MM-GBSA method coupled with residue-based free energy decomposition method was performed to explore drug-resistant mechanisms of the mutated EGFR.

Funder

National Natural Science Foundation of China

Shandong Jiaotong University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA06844E

Reference93 articles.

1. The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification.

2. Epidermal Growth Factor Receptor in Non–Small-Cell Lung Carcinomas: Correlation Between Gene Copy Number and Protein Expression and Impact on Prognosis