Discovery of fluorescent 3-heteroarylcoumarin derivatives as novel inhibitors of anaplastic lymphoma kinase-Reference-Cited by-同舟云学术

Discovery of fluorescent 3-heteroarylcoumarin derivatives as novel inhibitors of anaplastic lymphoma kinase

Published:2019 Issue:1 Volume:17 Page:186-194
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mah Shinmee¹²³⁴⁵,Jang Jaebong⁵⁶³⁴,Song Daesun¹²³⁴,Shin Yongje¹²³⁴⁵,Latif Muhammad⁵⁶³⁴⁷^ORCID,Jung Yongwon¹²³⁴,Hong Sungwoo¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Korea Advanced Institute of Science and Technology (KAIST)

3. Daejeon 34141

4. Republic of Korea

5. Center for Catalytic Hydrocarbon Functionalizations

6. Institute for Basic Science (IBS)

7. Centre for Genetics and Inherited Diseases (CGID)

Abstract

Coumarin-based ALK inhibitors were identified as a new template for the development of novel fluorescent ALK inhibitors, which can be tracked using microscopy techniques.

Funder

Institute for Basic Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02874E

Reference44 articles.

1. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

2. Anaplastic lymphoma kinase: signalling in development and disease

3. Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer

4. Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer

5. ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements: report of 6 cases

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