Tunable synthesis of quinolinone-fused isoquinolines through sequential one-pot nucleophilic addition and palladium-catalyzed intramolecular C

Tunable synthesis of quinolinone-fused isoquinolines through sequential one-pot nucleophilic addition and palladium-catalyzed intramolecular C–H alkenylation

Published:2019 Issue:2 Volume:17 Page:321-332
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Li Xue¹²³⁴⁵,Bian Yunyun¹²³,Chen Xin¹²³⁴⁵,Zhang Hang¹²³,Wang Wei¹²³,Ren Sida¹²³,Yang Xuechen¹²³,Lu Chang¹²³,Chen Chunxia¹²³⁴⁵,Peng Jinsong¹²³^ORCID

Affiliation:

1. Department of Chemistry and Chemical Engineering

2. College of Science

3. P. R. China

4. Material Science and Engineering College

5. Northeast Forestry University

Abstract

An efficient sequential one-pot synthesis of N-fused heterocycles based on 4-quinolinone and isoquinoline scaffolds of biological interest has been developed.

Funder

Natural Science Foundation of Heilongjiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02437E

Reference36 articles.

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2. Bacterial Topoisomerase Inhibitors: Quinolone and Pyridone Antibacterial Agents

3. Origins of the Quinolone Class of Antibacterials: An Expanded “Discovery Story”

4. The chemistry and biological activity of heterocycle-fused quinolinone derivatives: A review

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