Silicon-bridged (1→1)-disaccharides: an umpoled glycomimetic scaffold-Reference-Cited by-同舟云学术

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Silicon-bridged (1→1)-disaccharides: an umpoled glycomimetic scaffold

Published:2022 Issue:38 Volume:20 Page:7613-7621
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Choutka Jan¹^ORCID,Kratochvíl Michal¹^ORCID,Císařová Ivana²,Pohl Radek³^ORCID,Kaminský Jakub³^ORCID,Parkan Kamil¹^ORCID

Affiliation:

1. Department of Chemistry of Natural Compounds, University of Chemistry and Technology, Prague, Technická 5, 166 28, Prague, Czech Republic

2. Department of Inorganic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 2030, 128 40, Prague, Czech Republic

3. Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 166 10, Prague, Czech Republic

Abstract

Lithiation of 2-oxyglycals enabled the synthesis of silicon-bridged (1→1)-disaccharide analogs. The properties of this group of unusual novel compounds were investigated by a combination of spectroscopy and in silico modelling.

Funder

Grantová Agentura České Republiky

Ministerstvo Školství, Mládeže a Tělovýchovy

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01161A

Reference34 articles.

1. From carbohydrate leads to glycomimetic drugs

2. Carbohydrate vaccines: developing sweet solutions to sticky situations?

3. Strategies for the Development of Glycomimetic Drug Candidates

4. S-Glycosides: synthesis of S-linked arabinoxylan oligosaccharides

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