Affiliation:
1. Department of Chemistry, Indian Institute of Technology Kanpur, Uttar Pradesh-208016, India
Abstract
The rapid rise of multidrug resistance in cancer demands the development of structurally and mechanistically unique drugs candidates. We report targeted covalent GPX4 modifiers as nanomolar inducers of ferroptosis in liver cancer cells.
Funder
Science and Engineering Research Board
Department of Biotechnology, Ministry of Science and Technology, India
Indian Council of Medical Research
Council of Scientific and Industrial Research, India
Indian Institute of Technology Kanpur
Department of Science and Technology, Ministry of Science and Technology, India
Publisher
Royal Society of Chemistry (RSC)