Mechanistic studies of 1,3-dipolar cycloadditions of bicyclic thioisomünchnones with alkenes. A computational rationale focused on donor–acceptor interactions

Author:

García de la Concepción Juan12345ORCID,Ávalos Martín12345,Cintas Pedro12345ORCID,Jiménez José L.12345,Light Mark E.6789ORCID

Affiliation:

1. Departamento de Química Orgánica e Inorgánica

2. Facultad de Ciencias-UEX

3. IACYS-Unidad de Química Verde y Desarrollo Sostenible

4. E-06006 Badajoz

5. Spain

6. Department of Chemistry

7. University of Southampton

8. Southampton SO17 1BJ

9. UK

Abstract

Unlike monocyclic mesoionic dipoles, bicyclic thioisomünchnones provide high levels of regio- and stereoselection leading to heteroatom-rich polycycles.

Funder

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference48 articles.

1. Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products , ed. A. Padwa and W. H. Pearson , John Wiley & Sons , New York , 2002

2. Asymmetric 1,3-dipolar cycloadditions

3. H. Suga and K.Itoh , in Methods and Applications of Cycloaddition Reactions in Organic Syntheses , ed. N. Nishiwaki , John Wiley & Sons , Hoboken, New Jersey , 2013 , pp. 175–204

4. Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions

5. Progress in 1,3-dipolar cycloadditions in the recent decade: an update to strategic development towards the arsenal of organic synthesis

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