Engineering an enhanced thrombin-based GLP-1 analog with long-lasting glucose-lowering and efficient weight reduction

Author:

Pan Hongchao1234,Xie Yini1567,Lu Wenying89107,Chen Yin1112137,Lu Zhao1415167,Zhen Jun1415167,Wang Weiwei89107ORCID,Shang Anquan117187ORCID

Affiliation:

1. Department of Laboratory Medicine

2. Shanghai Simple Gene Medical Laboratory

3. Shanghai 200025

4. P.R. China

5. The People's Hospital of Jiedong

6. Jieyang 515500

7. P. R. China

8. Department of Experimental Medicine Center

9. The Sixth People's Hospital of Yancheng City

10. Yancheng 224001

11. Key Laboratory of Biological Medicine

12. Department of Life Science and Technology

13. Jinan University

14. Key Laboratory of Drug Discovery for Metabolic Disease

15. China Pharmaceutical University

16. Nanjing

17. Tongji Hospital of Tongji University

18. Shanghai 200065

Abstract

Peptides are considered as potent therapeutic drugs primarily due to the exquisite potency and selectivity to targets.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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