Synthesis, characterization and biological evaluation of cationic organoruthenium(ii) fluorene complexes: influence of the nature of the counteranion-Reference-Cited by-同舟云学术

Synthesis, characterization and biological evaluation of cationic organoruthenium(ii) fluorene complexes: influence of the nature of the counteranion

Published:2019 Issue:35 Volume:48 Page:13396-13405
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Haghdoost Mohammad Mehdi¹²³⁴,Golbaghi Golara¹²³⁴,Guard Juliette¹²³⁴,Sielanczyk Sarah¹²³⁴,Patten Shunmoogum A.¹²³⁴,Castonguay Annie¹²³⁴^ORCID

Affiliation:

1. INRS – Centre Armand-Frappier Santé Biotechnology

2. Université du Québec

3. Laval

4. Canada

Abstract

In this study, the in vitro antiproliferative activity and the in vivo toxicity of ruthenium arene complexes bearing fluorene bidentate ligands was assessed in human breast cancer cells and on the development of zebrafish embryos, respectively.

Funder

Institut national de la recherche scientifique

Natural Sciences and Engineering Research Council of Canada

Fonds de Recherche du Québec - Santé

Canada Foundation for Innovation

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/DT/C9DT00143C

Reference52 articles.

1. Metal-based anticancer chemotherapeutic agents

2. The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials

3. Lipophilicity-antiproliferative activity relationship study leads to the preparation of a ruthenium(II) arene complex with considerable in vitro cytotoxicity against cancer cells and a lower in vivo toxicity in zebrafish embryos than clinically approved cis -platin

4. Ruthenium complexes with phenylterpyridine derivatives target cell membrane and trigger death receptors-mediated apoptosis in cancer cells

5. Acute toxic effects of ruthenium (II)/amino acid/diphosphine complexes on Swiss mice and zebrafish embryos

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