Allicin attenuated hepatic ischemia/reperfusion injury in mice by regulating PPARγ-IRAK-M-TLR4 signal pathway-Reference-Cited by-同舟云学术

Allicin attenuated hepatic ischemia/reperfusion injury in mice by regulating PPARγ-IRAK-M-TLR4 signal pathway

Published:2022 Issue:13 Volume:13 Page:7361-7376
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Li Weiwei¹^ORCID,Huang Rui¹²,Gong Xia³,Zhao Zizuo¹,Zhang Lidan¹^ORCID,Zhou Qin¹⁴,Jiang Xujie¹⁵,Tie Hongtao⁶^ORCID,Wan Jingyuan⁷^ORCID,Wang Bin¹^ORCID

Affiliation:

1. Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

2. Department of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang 310058, China

3. Department of Anatomy, Chongqing Medical University, Chongqing 400016, China

4. Department of Anesthesiology, Army Medical Center of PLA, Army Medical University, Chongqing 400042, China

5. Department of Anesthesiology, Chengdu Fifth People's Hospital, Sichuan 611130, China

6. Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

7. Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, China

Abstract

This study shows that allicin has a protective effect on hepatic I/R injury by inhibiting hepatic apoptosis, inflammation and oxidative stress. It may be involved in regulating PPARγ-IRAK-M-TLR4 signal pathway and could be used as a therapeutic drug.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO00751G

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