A differential-targeting core–shell microneedle patch with coordinated and prolonged release of mangiferin and MSC-derived exosomes for scarless skin regeneration

Author:

Lyu Shang123,Liu Qi12,Yuen Ho-Yin12,Xie Huizhi4,Yang Yuhe125,Yeung Kelvin Wai-Kwok4ORCID,Tang Chak-yin6ORCID,Wang Shuqi78ORCID,Liu Yaxiong9,Li Bin1011ORCID,He Yong3ORCID,Zhao Xin125ORCID

Affiliation:

1. Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR 999077, China

2. Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR 999077, China

3. State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China

4. Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR 999077, China

5. The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, Guangdong 518057, China

6. Department of Industrial & Systems Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR 999077, China

7. Tianfu Jincheng Laboratory, City of Future Medicine, Chengdu 641400, China

8. Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610065, China

9. Jihua Laboratory, Foshan, Guangdong 528000, China

10. Medical 3D Printing Center, Orthopedic Institute, Department of Orthopaedic Surgery, The First Affiliated Hospital, School of Biology & Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215006, China

11. Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu 215006, China

Abstract

A novel core–shell microneedle system was developed based on GelMA and PmLnDMA to achieve a fast release of mangiferin and prolonged release of hMSC derived exosomes, ultimately leading to fast and scarless wound healing.

Funder

National Natural Science Foundation of China

Basic and Applied Basic Research Foundation of Guangdong Province

Hong Kong Polytechnic University

Priority Academic Program Development of Jiangsu Higher Education Institutions

West China Hospital, Sichuan University

Publisher

Royal Society of Chemistry (RSC)

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