Deciphering substitution effects on reductive hydroalkoxylation of alkynyl aminols for stereoselective synthesis of morpholines and 1,4-oxazepanes: total synthesis of tridemorph and fenpropimorph

Abstract

Depending on the alkynyl-substitution, N-alkynyl aminols gave divergent outcomes of morpholines and 1,2-oxazepanes via reductive etherification. Further, the method was used for the total synthesis of the fungicides tridemorph and fenpropimorph.