Chloroformate-mediated ring cleavage of indole alkaloids leads to re-engineered antiplasmodial agents-Reference-Cited by-同舟云学术

Chloroformate-mediated ring cleavage of indole alkaloids leads to re-engineered antiplasmodial agents

Published:2024 Issue: Volume: Page:
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Schultz Daniel C.¹^ORCID,Chávez-Riveros Alejandra¹,Goertzen Michael G.¹,Brummel Beau R.¹,Paes Raphaella A.²^ORCID,Santos Natalia M.²,Tenneti Srinivasarao¹,Abboud Khalil A.³,Rocca James R.¹⁴,Seabra Gustavo¹,Li Chenglong¹,Chakrabarti Debopam²,Huigens Robert W.¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Center for Natural Product Drug Discovery & Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA

2. Division of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida 32826, USA

3. Department of Chemistry, University of Florida, Gainesville, Florida 32610, USA

4. McKnight Brain Institute, J H Miller Health Center, University of Florida, Gainesville, Florida 32610, USA

Abstract

A chloroformate-mediated ring cleavage of indole alkaloids enabled the rapid synthesis of 47 diverse and complex small molecules, including derivatives from reserpine that demonstrate interesting activities against Plasmodium falciparum parasites.

Funder

University of Florida

National Institute of General Medical Sciences

National Cancer Institute

Consejo Nacional de Ciencia y Tecnología

National Institute of Dental and Craniofacial Research

National Science Foundation

State of Florida

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00853G

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5. Stereodivergent Complexity-to-Diversity Strategy en Route to the Synthesis of Nature-Inspired Skeleta