Self-assembled three-dimensional hydrogels based on graphene derivatives and cerium oxide nanoparticles: scaffolds for co-culture of oligodendrocytes and neurons derived from neural stem cells

Author:

Polo Yurena1ORCID,Luzuriaga Jon2ORCID,Gonzalez de Langarica Sergio3ORCID,Pardo-Rodríguez Beatriz2ORCID,Martínez-Tong Daniel E.4,Tapeinos Christos56ORCID,Manero-Roig Irene27ORCID,Marin Edurne3ORCID,Muñoz-Ugartemendia Jone3ORCID,Ciofani Gianni5ORCID,Ibarretxe Gaskon2ORCID,Unda Fernando2ORCID,Sarasua Jose-Ramon3ORCID,Pineda Jose Ramon28ORCID,Larrañaga Aitor3ORCID

Affiliation:

1. Polimerbio, Donostia-San Sebastian, Spain

2. Cell Signaling Lab, Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain

3. Group of Science and Engineering of Polymeric Biomaterials (ZIBIO Group), Department of Mining, Metallurgy Engineering and Materials Science, POLYMAT, University of the Basque Country (UPV/EHU), Bilbao, Spain

4. Polymers and advanced materials: Physics, Chemistry and Technology, University of the Basque Country (UPV/EHU), Donostia-San Sebastian, Spain & Centro de Física de Materiales (UPV/EHU-CSIC), Donostia-San Sebastian, Spain

5. Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Pontedera, PI, Italy

6. Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

7. Université de Bordeaux IINS – UMR 5297, Bordeaux, France

8. Achucarro Basque Center for Neuroscience Fundazioa, Leioa, Spain

Abstract

Hybrid hydrogels based on graphene derivatives and cerium oxide nanoparticles support heterocellular cultures for nervous tissue regeneration. Antioxidant properties of the hydrogels allow the survival of both neurons and oligodendrocytes.

Funder

Eusko Jaurlaritza

H2020 Marie Skłodowska-Curie Actions

Ministerio de Ciencia e Innovación

Euskal Herriko Unibertsitatea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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