Inhibition and disaggregation of amyloid β protein fibrils through conjugated polymer–core thermoresponsive micelles-Reference-Cited by-同舟云学术

Inhibition and disaggregation of amyloid β protein fibrils through conjugated polymer–core thermoresponsive micelles

Published:2020 Issue:44 Volume:8 Page:10126-10135
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Geng Hao¹²³⁴,Yuan Hongbo⁵⁶⁷²³,Qiu Liang⁵⁶⁷²³^ORCID,Gao Dong⁵⁶⁷²³,Cheng Yongqiang⁸⁹¹⁰¹¹¹²,Xing Chengfen¹²³⁴⁵^ORCID

Affiliation:

1. School of Materials Science and Engineering

2. Hebei University of Technology

3. Tianjin 300401

4. P. R. China

5. Key Laboratory of Hebei Province for Molecular Biophysics

6. Institute of Biophysics

7. School of Science

8. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis

9. Ministry of Education

10. Key Laboratory of Analytical Science and Technology of Hebei Province

11. College of Chemistry and Environmental Science

12. Hebei University

Abstract

The micelles (CPMs) have a thermoresponsive surface and reactive oxygen species (ROS) generating core. At 37 °C, CPMs captured Aβ aggregates to inhibit and disaggregate aggregates under white-light irradiation, reducing Aβ-induced cytotoxicity.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hebei Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2020/TB/D0TB01863E

Reference51 articles.

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2. Pathways of Amyloid-β Aggregation Depend on Oligomer Shape

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