Carborane-based design of a potent vitamin D receptor agonist-Reference-Cited by-同舟云学术

Carborane-based design of a potent vitamin D receptor agonist

Published:2016 Issue:2 Volume:7 Page:1033-1037
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Otero Rocio¹²³⁴⁵^ORCID,Seoane Samuel⁶⁷⁸⁵,Sigüeiro Rita¹²³⁴⁵^ORCID,Belorusova Anna Y.⁹¹⁰¹¹¹²,Maestro Miguel A.¹³¹⁴¹⁵⁵^ORCID,Pérez-Fernández Roman⁶⁷⁸⁵^ORCID,Rochel Natacha⁹¹⁰¹¹¹²^ORCID,Mouriño Antonio¹²³⁴⁵^ORCID

Affiliation:

1. Departamento de Química Orgánica

2. Laboratorio de Investigación Ignacio Ribas

3. Universidad de Santiago de Compostela

4. 15782 Santiago de Compostela

5. Spain

6. Departamento de Fisiología–CIMUS

7. Universidad de Santiago

8. 15706 Santiago de Compostela

9. Department of Integrative Structural Biology

10. IGBMC - CNRS UMR7104 – Inserm U964

11. 67400 Illkirch

12. France

13. Departmento de Química Fundamental

14. Universidad de A Coruña

15. 15071 A Coruña

Abstract

The development of a promising clinical antitumor vitamin D analog possessing a side-chain o-carborane cluster that efficiently binds to VDR by unconventional dihydrogen bonding (BH⋯HN) is described.

Funder

Fundación Científica Asociación Española Contra el Cáncer

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C5SC03084F

Reference32 articles.

1. Dicarba-closo-dodecaboranes C2B10H12 and their derivatives

2. From Conventional to Unusual Enzyme Inhibitor Scaffolds: The Quest for Target Specificity