Discovery of novel β-elemene hybrids with hydrogen sulfide-releasing moiety possessing cardiovascular protective activity for the treatment of atherosclerosis-Reference-Cited by-同舟云学术

Discovery of novel β-elemene hybrids with hydrogen sulfide-releasing moiety possessing cardiovascular protective activity for the treatment of atherosclerosis

Published:2024 Issue:1 Volume:15 Page:151-164
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Zhu Wenjian¹,Wu Hongyu¹,He Chen¹,Zhu Huajian¹,Yao Hong¹,Cao Yun²,Shi Yueman³,Chen Xiaotong³,Feng Xue³,Xu Shengtao¹,Zhu Zheying⁴,Xu Jinyi¹^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China

2. Jinling High School, Nanjing, Jiangsu, 210005, China

3. 50 Dongbei Street Development Zone, CSPC Yuanda (Dalian) Pharmaceutical Co., Ltd, Dalian, Liaoning, 116600, China

4. Division of Molecular Therapeutics & Formulation, School of Pharmacy, The University of Nottingham, University Park Campus, Nottingham NG7 2RD, UK

Abstract

Herein, a series of novel β-elemene hybrids with different types of hydrogen sulfide (H2S) donors was designed and synthesized for the first time.

Funder

China Pharmaceutical University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00447C

Reference27 articles.

1. In Search for Genes Related to Atherosclerosis and Dyslipidemia Using Animal Models

2. Recent insights into the cellular biology of atherosclerosis

3. Management of residual risk after statin therapy

4. Statin myopathy: the fly in the ointment for the prevention of cardiovascular disease in the 21st century?

5. Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed