A survey of stapling methods to increase affinity, activity, and stability of ghrelin analogues-Reference-Cited by-同舟云学术

A survey of stapling methods to increase affinity, activity, and stability of ghrelin analogues

Published:2024 Issue:1 Volume:15 Page:254-266
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Esteban Juan J.¹,Mason Julia R.¹,Kaminski Jakob¹,Ramachandran Rithwik²,Luyt Leonard G.¹³⁴^ORCID

Affiliation:

1. Department of Chemistry, University of Western Ontario, 1151 Richmond Street, London, Ontario, N6A 3K7, Canada

2. Department of Physiology and Pharmacology, University of Western Ontario, 1151 Richmond Street, London, Ontario N6A 5C1, Canada

3. Departments of Medical Imaging and Oncology, University of Western Ontario, 1151 Richmond Street, London, Ontario, N6A 3K7, Canada

4. London Regional Cancer Program, Lawson Health Research Institute, 800 Commissioners Road East, London, Ontario, N6A 4L6, Canada

Abstract

In this paper we present a survey of stapling methods for the peptide ghrelin, resulting in the discovery of ghrelin analogues with improved affinity, stability and efficacy.

Funder

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00441D

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4. Structure−Function Studies on the New Growth Hormone-Releasing Peptide, Ghrelin: Minimal Sequence of Ghrelin Necessary for Activation of Growth Hormone Secretagogue Receptor 1a

5. Effects of ghrelin in energy balance and body weight homeostasis