Newly synthesized 6-substituted piperazine/phenyl-9-cyclopentyl containing purine nucleobase analogs act as potent anticancer agents and induce apoptosis <i>via</i> inhibiting Src in hepatocellular carcinoma cells-Reference-Cited by-同舟云学术

Newly synthesized 6-substituted piperazine/phenyl-9-cyclopentyl containing purine nucleobase analogs act as potent anticancer agents and induce apoptosis via inhibiting Src in hepatocellular carcinoma cells

Published:2023 Issue:12 Volume:14 Page:2658-2676
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Bilget Guven Ebru¹²^ORCID,Durmaz Sahin Irem³⁴,Altiparmak Duygu¹,Servili Burak⁵^ORCID,Essiz Sebnem²⁵^ORCID,Cetin-Atalay Rengul⁶⁷,Tuncbilek Meral¹

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06560, Yenimahalle, Ankara, Turkey

2. Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Kadir Has University, 34083, Cibali-Fatih, Istanbul, Turkey

3. Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, 06800, Bilkent, Ankara, Turkey

4. School of Medicine, Koc University, 34450, Sarıyer, İstanbul, Turkey

5. Graduate School of Science and Engineering, Bioinformatics and Genetics Program, Kadir Has University, Fatih 34083, Istanbul, Turkey

6. Cancer System Biology Laboratory, CanSyL, Graduate School of Informatics, Middle East Technical University, 06800, Ankara, Turkey

7. Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL, 60637, USA

Abstract

When the purine analog, compound 19, is introduced to liver cancer cells, selectively interacting with ALK and BTK, phospho-Src, phospho-Rb, cyclin E, and cdk2 levels decrease, thereby leading the cell to apoptosis.

Funder

Türkiye Bilimsel ve Teknolojik Araştırma Kurumu

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00440F

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