Dendritic nanoconjugates for intracellular delivery of neutral oligonucleotides-Reference-Cited by-同舟云学术

Dendritic nanoconjugates for intracellular delivery of neutral oligonucleotides

Published:2015 Issue:29 Volume:7 Page:12302-12306
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Ming Xin¹²³⁴,Wu Lin¹²³⁴⁵,Carver Kyle¹²³⁴,Yuan Ahu¹²³⁴⁶,Min Yuanzeng⁷⁸³⁴

Affiliation:

1. Division of Molecular Pharmaceutics

2. UNC Eshelman School of Pharmacy

3. University of North Carolina

4. Chapel Hill, USA

5. Clinical Research Center

6. State Key Laboratory of Pharmaceutical Biotechnology

7. Department of Radiation Oncology

8. Lineberger Comprehensive Cancer Center

Abstract

Conjugation of neutral oligonucleotides (ONs) with PAMAM dendrimers resulted in ultra-small nanoconjugates that combine superior ON delivery and reduced cytotoxicity.

Funder

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2015/NR/C5NR01665G

Reference24 articles.

1. RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

2. Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

3. Cellular delivery of siRNA and antisense oligonucleotides via receptor-mediated endocytosis

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