Synthesis of a novel carboxybetaine copolymer with different spacer lengths and inhibition of nonspecific protein adsorption on its polymer film

Abstract

Herein, we designed and synthesized a thermally stable carboxybetaine copolymer with a one- or three-carbon spacer between ammonium and carboxylate groups (CBMA1 and CBMA3) to create an anti-nonspecific adsorption surface with the ability to immobilize antibodies.