Roles of Epigenetic Modifications in Male Reproductive Toxicity

Author:

Zhang Xueguang1,Guo Juncen1,Xu Wenming2

Affiliation:

1. Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China

2. Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China xuwenming@scu.edu.cn

Abstract

Spermatogenesis is a highly specialized process resulting in the formation of functional spermatozoa for male reproduction and consists of the mitotic division of spermatogonia, meiosis of spermatocytes, and a metamorphic change (spermiogenesis). Spermatogenesis requires specialized epigenetic regulation to generate functional spermatozoa. During mitotic proliferation and meiosis of spermatogonia and spermatocytes, respectively, and the metamorphic changes of spermiogenesis, epigenetic modifications including DNA methylation, histone modifications and RNA modifications are essential. Of particular note, N6-methyladenosine (m6A) modifications of RNA emerge as crucial epigenetic changes for spermatogenesis. After fertilization, decondensation of the male pronucleus is accompanied by epigenetic reprogramming. Exposure to environmental toxicants can impair male reproduction by altering gene expression and epigenetic profiles, compromising fertility and offspring health. This chapter presents a systematic review of the role of environmental pollution-induced epigenetic alterations in male reproductive toxicity. Elucidating the links between environmental toxicants, epigenetic disruption of spermatogenesis, and impaired male fertility or offspring health is crucial to understand and address this public health issue.

Publisher

Royal Society of Chemistry

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