CRISPR/Cas-based electrochemical diagnostics

Abstract

Due to the limited time pass (less than 5 years) for developing CRISPR/Cas-based electrochemical detection platforms, this field is very new. The number of experimental studies is limited, and this field does not take a long developmental path yet. Therefore expansion of ideas is limited based on some pioneering research. However, this does not diminish the importance and potential of this field. There is vast potential in the field of CRISPR/Cas-based diagnostics; as the electrochemical detection systems proved their abilities in the past, merging these two categories will mark a bright future with applications in very diverse subjects. This chapter attempts to brighten the potential of applications in this field. Despite the limited number of researches in this field, the diverse application of CRISPR/Cas-based electrochemical biosensors are reviewed here, which implicitly confirms the potential of this field. Due to the analytical advantage of the electrochemical-based detection system, in comparison to the other methods, electrochemical CRISPR/Cas-based detection systems will significantly impact improving public health quality through developing sensitive, reliable, and affordable point of care diagnostic devices and tests.