Injectable Smart Hydrogels for Ophthalmic Applications

Author:

Nejad Zohreh Mousavi12,McCarthy Helen O.34,Levingstone Tanya J.12567,Dunne Nicholas J.12345678910

Affiliation:

1. aSchool of Mechanical and Manufacturing Engineering, Dublin City University, D09 Y074 Dublin, Ireland

2. bCentre for Medical Engineering Research, School of Mechanical and Manufacturing Engineering, Dublin City University, D09 Y074 Dublin, Ireland

3. cSchool of Pharmacy, Queen’s University Belfast, Belfast BT9 7BL, UK

4. dSchool of Chemical Science, Dublin City University, D09 Y074 Dublin, Ireland

5. eAdvanced Manufacturing Research Centre (I-Form), School of Mechanical and Manufacturing Engineering, Dublin City University, D09 Y074 Dublin, Ireland

6. fAdvanced Materials and Bioengineering Research Centre (AMBER), Trinity College Dublin, D02 PN40 Dublin, Ireland

7. gAdvanced Processing Technology Research Centre, Dublin City University, D09 Y074 Dublin, Ireland

8. hBiodesign Europe, Dublin City University, D09 Y074 Dublin, Ireland

9. iDepartment of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, D02 PN40 Dublin, Ireland

10. jTrinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, D02 PN40 Dublin, Ireland nicholas.dunne@dcu.ie

Abstract

In recent years, the field of injectable smart hydrogels for ophthalmic applications has gained considerable attention. These remarkable materials have emerged as promising candidates for addressing a broad spectrum of ocular diseases and conditions. The inherent properties of injectable smart hydrogels, including sustained drug delivery, tissue regeneration promotion, and therapeutic enhancement, have fuelled their growing significance in ophthalmology. This book chapter offers an in-depth exploration of the current research landscape, focusing on the latest developments in the design and application of injectable smart hydrogels for ocular purposes. The essential design criteria for these hydrogels are discussed and a comprehensive overview of their versatile applications in treating ophthalmic conditions such as corneal regeneration, ocular drug delivery, vitreous substitutes, and glaucoma treatment is presented. By illuminating the transformative potential of injectable smart hydrogels, this chapter aims to highlight their capacity to revolutionise the field of ophthalmic care.

Publisher

Royal Society of Chemistry

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