Quo Vadis

Abstract

Ubiquitous and prominent circadian rhythms are only one component of a rich inter-modulating multi-frequency time structure. While a molecular mechanism underlying circadian rhythms has been uncovered, a molecular basis for other rhythmic components is now emerging. Evidence for a partially endogenous broader-than-circadian time structure awaits further investigation into the underlying mechanisms since it may offer added chronotherapeutic applications in the clinic, as already shown empirically. Much attention is devoted to the discovery and applications of small molecules targeting the circadian clock directly, representing another area that is rapidly evolving and offering a novel approach to treat a host of different conditions where the restoration of a well-functioning circadian system plays a central role.