A practical entry to β-aryl-β-alkyl amino alcohols: application to the synthesis of a potent BACE1 inhibitor-Reference-Cited by-同舟云学术

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A practical entry to β-aryl-β-alkyl amino alcohols: application to the synthesis of a potent BACE1 inhibitor

Published:2012 Issue:33 Volume:10 Page:6758
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Delgado Oscar,Monteagudo Antonio,Van Gool Michiel,Trabanco Andrés A.,Fustero Santos

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2012/OB/C2OB25845E

Reference22 articles.

1. The secretases: enzymes with therapeutic potential in Alzheimer disease

2. β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

3. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

4. Aβ-Generating Enzymes

5. Alzheimer's Disease: Genes, Proteins, and Therapy

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