SARS-CoV-2-induced disruption of a vascular bed in a microphysiological system caused by type-I interferon from bronchial organoids-Reference-Cited by-同舟云学术

SARS-CoV-2-induced disruption of a vascular bed in a microphysiological system caused by type-I interferon from bronchial organoids

Published:2024 Issue:16 Volume:24 Page:3863-3879
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Fujimoto Kazuya¹^ORCID,Kameda Yoshikazu¹^ORCID,Nagano Yuta¹,Deguchi Sayaka²,Yamamoto Takuya²³⁴^ORCID,Krol Rafal P.⁵^ORCID,Gee Peter⁶,Matsumura Yasufumi⁷^ORCID,Okamoto Toru⁸^ORCID,Nagao Miki⁷^ORCID,Takayama Kazuo²^ORCID,Yokokawa Ryuji¹^ORCID

Affiliation:

1. Department of Micro Engineering, Kyoto University, Kyoto daigaku-Katsura, Nishikyo-ku, Kyoto 615-8540, Japan

2. Center for iPS cell Research and Application (CiRA), Kyoto University, Shogoin-Kawahara-cho 53, Sakyo-ku, Kyoto, 606-8507, Japan

3. Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan

4. Medical-risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Shogoin-Kawahara-cho 53, Sakyo-ku, Kyoto, 606-8507, Japan

5. Research and Development Center, CiRA Foundation, Shogoin-Kawahara-cho 53, Sakyo-ku, Kyoto, 606-8397, Japan

6. MaxCyte Inc., Gaithersburg, MD 20878, USA

7. Department of Clinical Laboratory medicine, Kyoto University Graduate School of Medicine, Shogoin-Kawahara-cho 53, Sakyo-ku, Kyoto, 606-8507, Japan

8. Department of Microbiology, School of Medicine, Juntendo University, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421, Japan

Abstract

3D co-culture of vascular bed and bronchial organoids in microfluidic device was established to assess SARS-CoV-2 effect, showing vascular bed damage upon the virus application, despite the absence of infection in the vascular endothelial cells.

Funder

Japan Agency for Medical Research and Development

Kyoto University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/LC/D3LC00768E

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