A nitroalkane-based approach to one-pot three-component synthesis of isocryptolepine and its analogs with potent anti-cancer activities-Reference-Cited by-同舟云学术

A nitroalkane-based approach to one-pot three-component synthesis of isocryptolepine and its analogs with potent anti-cancer activities

Published:2018 Issue:64 Volume:8 Page:36980-36986
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Aksenov Nicolai A.¹²³⁴^ORCID,Aksenov Alexander V.¹²³⁴^ORCID,Kornienko Alexander⁵⁶⁷⁸^ORCID,De Carvalho Annelise⁹¹⁰¹¹¹²¹³,Mathieu Véronique⁹¹⁰¹¹¹²¹³,Aksenov Dmitrii A.¹²³⁴,Ovcharov Sergei N.¹²³⁴,Griaznov Georgii D.¹¹⁴¹⁵⁸,Rubin Michael¹²³⁴¹^ORCID

Affiliation:

1. Department of Chemistry

2. North Caucasus Federal University

3. Stavropol 355009

4. Russian Federation

5. Department of Chemistry and Biochemistry

6. Texas State University

7. San Marcos

8. USA

9. Department of Pharmacotherapy and Pharmaceutics

10. Faculté de Pharmacie

11. Université Libre de Bruxelles

12. Brussels

13. Belgium

14. University of Kansas

15. Lawrence

Abstract

An improved one-pot three-component synthesis involving electrophilically activated nitroalkanes allowed for efficient preparation of indoloquinolines with potent anticancer activities.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA08155G

Reference38 articles.

1. Indoloquinolines: Possible Biogenesis from Common Indole Precursors and their Synthesis using Domino Strategies

2. Isolation, Biological Activities and Synthesis of Indoloquinoline Alkaloids: Cryptolepine, Isocryptolepine and Neocryptolepine

3. Discovery and Development of Natural Product-Derived Chemotherapeutic Agents Based on a Medicinal Chemistry Approach