An efficient PeT based fluorescent probe for mapping mitochondrial oxidative stress produced <i>via</i> the Nox2 pathway-Reference-Cited by-同舟云学术

An efficient PeT based fluorescent probe for mapping mitochondrial oxidative stress produced via the Nox2 pathway

Published:2022 Issue:13 Volume:10 Page:2230-2237
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Baruah Mousumi¹^ORCID,Jana Anal¹^ORCID,Ali Mudassar²,Mapa Koyeli²,Samanta Animesh¹^ORCID

Affiliation:

1. Molecular Sensors and Therapeutics Research Laboratory, Department of Chemistry, Shiv Nadar University, Delhi NCR, NH 91, Tehsil Dadri, Gautam Buddha Nagar, Uttar Pradesh, 201314, India

2. Protein Homeostasis Laboratory, Department of Life Sciences, Shiv Nadar University, Delhi NCR, NH 91, Tehsil Dadri, Gautam Buddha Nagar, Uttar Pradesh, 201314, India

Abstract

A new pentacyclic pyridinium-based mitochondria-specific fluorescent probe, PM-S, exhibited a specific turn-on fluorescence response towards hypochlorous acid and enabled imaging of oxidative stress in mitochondria through Nox2 activation.

Funder

Science and Engineering Research Board

Shiv Nadar University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D2TB00356B

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