The landscape of <i>N</i>6-methyladenosine modification patterns and altered transcript profiles in the cardiac-specific deletion of natriuretic peptide receptor A-Reference-Cited by-同舟云学术

The landscape of N6-methyladenosine modification patterns and altered transcript profiles in the cardiac-specific deletion of natriuretic peptide receptor A

Published:2023 Issue:2 Volume:19 Page:105-125
ISSN:2515-4184
Container-title:Molecular Omics
language:en
Short-container-title:Mol. Omics

Author:

Shen Xi¹²^ORCID,Chang Pan³,Zhang Xiaomeng³,Zhang Jing³,Wang Xihui³,Quan Zhuo¹²,Wang Pengli¹²,Liu Tian¹²,Niu Yan¹²,Zheng Rong¹²,Chen Baoying⁴,Yu Jun¹²

Affiliation:

1. Clinical Experimental Centre, Xi’an International Medical Centre Hospital, 777, Xitai Road, Hightech-zone, Xi’an, Shaanxi 710100, P. R. China

2. Xi'an Engineering Technology Research Center for Cardiovascular Active Peptides, P. R. China

3. Department of Cardiology, the Second Affiliated Hospital, Xi’an Medical University, Xi’an, Shaanxi 710038, P. R. China

4. Imaging Diagnosis and Treatment Centre, Xi’an International Medical Centre Hospital, 777, Xitai Road, Hightech-zone, Xi’an, Shaanxi 710100, P. R. China

Abstract

By conjoint analysis of m6A modification patterns and transcript profiles in cardiac NPRA CKO mice, we show that Pdk4 and its m6A modification might be crucial regulators in metabolic imbalance and insulin resistance impacted by NP signalling.

Funder

Natural Science Foundation of Shaanxi Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MO/D2MO00201A

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