Modeling mechanisms underlying differential inflammatory responses to COVID-19 in type 2 diabetes using a patient-derived microphysiological organ-on-a-chip system-Reference-Cited by-同舟云学术

Modeling mechanisms underlying differential inflammatory responses to COVID-19 in type 2 diabetes using a patient-derived microphysiological organ-on-a-chip system

Published:2023 Issue:20 Volume:23 Page:4514-4527
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Negi Vinny¹^ORCID,Gavlock Dillon²,Miedel Mark T.²,Lee Jeong Kyung¹,Shun Tongying²,Gough Albert²^ORCID,Vernetti Lawrence²^ORCID,Stern Andrew M.²,Taylor D. Lansing²,Yechoor Vijay K.¹

Affiliation:

1. Diabetes and Beta Cell Biology Center, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA, USA

2. Drug Discovery Institute and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA

Abstract

Human Liver-on-a-chip microphysiological system was developed to model and COVID-19 infection in T2D patients and to screen drugs to mitigate cytokine storm syndrome and expedite drug development.

Funder

National Institutes of Health

National Center for Advancing Translational Sciences

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/LC/D3LC00285C

Reference77 articles.

1. Causes of death and comorbidities in hospitalized patients with COVID-19

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5. Evaluation and management of COVID-19-related severity in people with type 2 diabetes

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