ONIOM calculations on serotonin degradation by monoamine oxidase B: insight into the oxidation mechanism and covalent reversible inhibition-Reference-Cited by-同舟云学术

ONIOM calculations on serotonin degradation by monoamine oxidase B: insight into the oxidation mechanism and covalent reversible inhibition

Published:2016 Issue:39 Volume:14 Page:9239-9252
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Cakir Kubra¹²³⁴⁵,Erdem Safiye Sag¹²³⁴⁵^ORCID,Atalay Vildan Enisoglu⁶⁷⁸⁹⁵

Affiliation:

1. Marmara University

2. Department of Chemistry

3. Faculty of Arts and Sciences

4. 34722 Göztepe

5. Turkey

6. Üsküdar University

7. Department of Bioengineering

8. Faculty of Engineering and Natural Sciences

9. 34662 Üsküdar

Abstract

We propose a hybrid mechanism for MAO where the formation of FAD-N5-ylide causes a reversible covalent inhibition, which can be modulated for designing superior therapeutics.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01175F

Reference62 articles.

1. Monoamine oxidase A and B substrates: probing the pathway for drug development

2. Inhibitor Design for Monoamine Oxidases

3. Serotonin and Cancer: What Is the Link?

4. M. Bortolato , K.Chen and J. C.Shih, in Handbook of the Behavioral Neurobiology of Serotonin, ed. C. P. Müller and B. L. Jacobs, Academic Press, London, 1st edn, 2010, pp. 203–218

5. What’s in a covalent bond?

Cited by 35 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Application of monoamine oxidase in organic synthesis;Chem Catalysis;2024-07

2. Why Does Monoamine Oxidase (MAO) Catalyze the Oxidation of Some Tetrahydropyridines?;ChemBioChem;2024-04-11

3. Computational analysis of hydride and proton transfer steps in l-lactate oxidase based on QM and QM–MM methods;Journal of Molecular Structure;2024-01

4. Catalysis & inhibition issues associated with Monoamine Oxidase (MAO). How unusually low α-C-H bond dissociation energies may open the door to single electron transfer;Chemical Thermodynamics and Thermal Analysis;2023-12

5. Computational Mechanistic Study of l-Aspartate Oxidase by ONIOM Method;ACS Omega;2023-05-25