Investigation of Heck coupling on 6-bromo[2,3-d]thienopyrimidines for construction of new EGFR inhibitor lead structures-Reference-Cited by-同舟云学术

Investigation of Heck coupling on 6-bromo[2,3-d]thienopyrimidines for construction of new EGFR inhibitor lead structures

Published:2017 Issue:30 Volume:7 Page:18569-18577
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Bysting F.¹²³⁴⁵,Bugge S.¹²³⁴⁵,Sundby E.⁶³⁴⁵^ORCID,Hoff B. H.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Faculty of Natural Sciences and Technology

3. Norwegian University of Science and Technology (NTNU)

4. NO-7491 Trondheim

5. Norway

6. Department of Materials Science and Engineering

Abstract

With the aim of identifying new lead structures for EGFR inhibition, a study of palladium catalysed Heck coupling between (R)-6-bromo-N-(1-phenylethyl)thieno[2,3-d]pyrimidin-4-amine and various acrylates was performed.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA01961K

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