Photostable far-red emitting pluronic silicate nanoparticles: perfect blood pool fluorophores for biphotonic in vivo imaging of the leaky tumour vasculature

Author:

Zheng Zheng12345,Caraguel Flavien678910,Liao Yuan-Yuan12345,Andraud Chantal12345,van der Sanden Boudewijn678910,Bretonnière Yann12345

Affiliation:

1. Univ Lyon

2. ENS de Lyon

3. CNRS UMR 5182

4. Université Lyon 1

5. Laboratoire de Chimie

6. PF of Intravital Microscopy France Life Imaging & CEA-INSERM-Grenoble Alps University

7. UMR S 1036

8. Biology of Cancer and Infection

9. Grenoble

10. France

Abstract

A new non-diffusible fluorescent probe for two photon microscopy, comprising a hydrophobic push-pull dye in the apolar core of Pluronic F127–silica nanoparticles, shows intense red emission (Φf 39% at 650 nm) and two-photon absorption properties in the NIR.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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