Probing transient non-native states in amyloid beta fiber elongation by NMR-Reference-Cited by-同舟云学术

Probing transient non-native states in amyloid beta fiber elongation by NMR

Published:2019 Issue:31 Volume:55 Page:4483-4486
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Brender Jeffrey R.¹²³⁴⁵^ORCID,Ghosh Anirban⁶⁷⁸⁹,Kotler Samuel A.⁵²³⁴,Krishnamoorthy Janarthanan¹²³⁴⁵,Bera Swapna⁶⁷⁸⁹,Morris Vanessa⁵¹⁰¹¹^ORCID,Sil Timir Baran¹²¹³⁹,Garai Kanchan¹²¹³⁹,Reif Bernd⁵¹⁰¹¹^ORCID,Bhunia Anirban¹²³⁴⁵^ORCID,Ramamoorthy Ayyalusamy¹²³⁴⁵^ORCID

Affiliation:

1. Biophysics

2. University of Michigan

3. Ann Arbor

4. USA

5. Department of Chemistry

6. Department of Biophysics

7. Bose Institute

8. Kolkata 700054

9. India

10. Technische Universität München

11. Germany

12. TIFR Centre for Interdisciplinary Sciences

13. Hyderabad 500107

Abstract

Using NMR to probe transient binding of Aβ_1–40 monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19–K28 and a lesser degree of interaction near the C-terminus (L34–G37).

Funder

National Institute on Aging

Council of Scientific and Industrial Research, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC01067J

Reference30 articles.

1. Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

2. Secondary nucleation in amyloid formation

3. Successive Stages of Amyloid-β Self-Assembly Characterized by Solid-State Nuclear Magnetic Resonance with Dynamic Nuclear Polarization

4. Elongation dynamics of amyloid fibrils: A rugged energy landscape picture

5. Toward a Molecular Theory of Early and Late Events in Monomer to Amyloid Fibril Formation

Cited by 48 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Peptide-Based Strategies: Combating Alzheimer’s Amyloid β Aggregation through Ergonomic Design and Fibril Disruption;Biochemistry;2024-09-10

2. An NMR Toolkit to Probe Amyloid Oligomer Inhibition in Neurodegenerative Diseases: From Ligand Screening to Dissecting Binding Topology and Mechanisms of Action;ChemPlusChem;2024-06-04

3. Application of singular value decomposition analysis: Insights into the complex mechanisms of amyloidogenesis;Biophysical Chemistry;2024-03

4. Amyloid β-Peptide Segment Conjugated Side-Chain Proline-Based Polymers as Potent Inhibitors in Lysozyme Amyloidosis;Bioconjugate Chemistry;2024-02-29

5. Molecular Insights into the Dynamics of Amyloid Fibril Growth: Elongation and Lateral Assembly of GNNQQNY Protofibrils;ACS Chemical Neuroscience;2024-01-18