A dual action coumarin-camptothecin polymer for light responsive drug release and photodynamic therapy-Reference-Cited by-同舟云学术

A dual action coumarin-camptothecin polymer for light responsive drug release and photodynamic therapy

Published:2024 Issue:2 Volume:15 Page:54-58
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Shaw Paige A.¹^ORCID,Klausen Maxime¹²^ORCID,Bradley Mark¹³^ORCID

Affiliation:

1. EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, EH9 3FJ, Edinburgh, UK

2. Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ UK

3. Precision Healthcare University Research Institute, Queen Mary University of London, Empire House, London, E1 1HH, UK

Abstract

A light-responsive polymer caging the anticancer drug camptothecin was prepared by RAFT polymerisation. The water-soluble polymer efficiently killed cancer cells under irradiation thanks to simultaneous camptothecin uncaging and photodynamic therapy.

Funder

Engineering and Physical Sciences Research Council

Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2024/PY/D3PY01137B

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