Selective aliphatic carbon–hydrogen bond activation of protected alcohol substrates by cytochrome P450 enzymes-Reference-Cited by-同舟云学术

Selective aliphatic carbon–hydrogen bond activation of protected alcohol substrates by cytochrome P450 enzymes

Published:2014 Issue:15 Volume:12 Page:2479-2488
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Bell Stephen G.¹²³⁴⁵,Spence Justin T. J.¹²³,Liu Shenglan¹²³,George Jonathan H.¹²³,Wong Luet-Lok⁴⁵⁶⁷

Affiliation:

1. School of Chemistry and Physics

2. University of Adelaide

3. , Australia

4. Department of Chemistry

5. University of Oxford

6. Inorganic Chemistry Laboratory

7. Oxford, UK

Abstract

Protected cyclohexanol and cyclohex-2-enol substrates were efficiently and selectively oxidised by different P450cam mutants providing a general methodology for generating substituted diols using biocatalysts.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C3OB42417K

Reference66 articles.

1. Cytochrome P450: Structure, Mechanism, and Biochemistry , ed. P. R. Ortiz de Montellano , Kluwer Academic/Plenum Publishers , New York , 3rd edn, 2005

2. A. Sigel , H.Sigel and R.Sigel , The Ubiquitous Roles of Cytochrome P450 Proteins , John Wiley & Sons , 1st edn, 2007 , vol. 3

3. Common and Uncommon Cytochrome P450 Reactions Related to Metabolism and Chemical Toxicity

4. Complex reactions catalyzed by cytochrome P450 enzymes

5. S. G. Bell , N.Hoskins , C. J. C.Whitehouse and L. L.Wong , Design and Engineering of Cytochrome P450 Systems , John Wiley & Sons , 1st edn, 2007 , vol. 3 , ch. 14, pp. 437–476

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