Synthetic investigation on chirally pure Mannich derivatives of pseudophenylpropanolamine and their anticancer properties against HepG-2 cells with inhibition of JAK2/STAT3-Reference-Cited by-同舟云学术

Synthetic investigation on chirally pure Mannich derivatives of pseudophenylpropanolamine and their anticancer properties against HepG-2 cells with inhibition of JAK2/STAT3

Published:2016 Issue:99 Volume:6 Page:96946-96962
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Balachandran C.¹²³⁴,Rao K. Chennakesava⁵⁶⁷⁸⁹,Arun Y.⁹¹⁰¹¹⁸^ORCID,Emi N.¹²³⁴,Yamamoto N.¹²¹³²³⁴,Inaguma Y.¹²³⁴,Okamoto A.¹²³⁴,Easwaramoorthi K.⁵⁶⁷⁸,Perumal P. T.⁹¹⁰¹¹⁸

Affiliation:

1. Department of Hematology and Oncology

2. Fujita Health University

3. Toyoake

4. Japan

5. Research & Development Centre

6. Malladi Drugs & Pharmaceuticals Ltd.

7. Chennai-600 124

8. India

9. Organic & Bio-Organic Chemistry Laboratory

10. CSIR-Central Leather Research Institute

11. Chennai 600 020

12. Laboratory of Molecular Biology

13. Institute of Joint Research

Abstract

In vitro and in vivo anticancer activity of compound 3a was proved as a novel blocker of JAK2/STAT3 signaling pathway and exerts both anti-proliferative and apoptotic activities in HepG-2 cells with xenograft mice model.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA22480F

Reference41 articles.

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3. The ?1-agonist phenylephrine inhibits voltage-gated Ca2+-channels in vascular smooth muscle cells of rabbit ear artery

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