Mechanisms and energetics for N-glycosidic bond cleavage of protonated 2′-deoxyguanosine and guanosine-Reference-Cited by-同舟云学术

Mechanisms and energetics for N-glycosidic bond cleavage of protonated 2′-deoxyguanosine and guanosine

Published:2016 Issue:4 Volume:18 Page:2968-2980
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Wu R. R.¹²³⁴,Chen Yu¹²³⁴,Rodgers M. T.¹²³⁴

Affiliation:

1. Department of Chemistry

2. Wayne State University

3. Detroit

4. USA

Abstract

TCID thresholds of [dGuo/Guo+H]⁺ indicate that 2′-hydroxyl strengthens glycosidic bond stability but slightly weakens the competition between the two primary dissociation pathways of [Guo+H]⁺vs. [dGuo+H]⁺.

Funder

Directorate for Mathematical and Physical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CP/C5CP05738H

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