Identification of potent catalytic inhibitors of human DNA topoisomerase II by structure-based virtual screening-Reference-Cited by-同舟云学术

Identification of potent catalytic inhibitors of human DNA topoisomerase II by structure-based virtual screening

Published:2018 Issue:7 Volume:9 Page:1142-1146
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Dong Guoqiang¹²³⁴⁵,Wu Ying¹²³⁴⁵,Sun Ying⁶⁷⁵⁸,Liu Na¹²³⁴⁵,Wu Shanchao¹²³⁴⁵,Zhang Wannian¹²³⁴⁵,Sheng Chunquan¹²³⁴⁵^ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. School of Pharmacy

3. Second Military

4. Medical University

5. Shanghai 200433

6. Naval Medical Research Institute

7. Second Military Medical University

8. China

Abstract

Structure-based virtual screening was performed and led to 14 novel Top2 catalytic inhibitors. Compound 8 was proven to be a Top2 catalytic inhibitor and showed good in vitro antiproliferative activity. It holds great potential for further hit-to-lead development in anticancer drug discovery.

Funder

Shanghai Education Development Foundation

Shanghai Municipal Education Commission

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C8MD00219C

Reference25 articles.

1. Drugging Topoisomerases: Lessons and Challenges