Charging nanoparticles: increased binding of Gd@C82(OH)22 derivatives to human MMP-9-Reference-Cited by-同舟云学术

Charging nanoparticles: increased binding of Gd@C82(OH)22 derivatives to human MMP-9

Published:2018 Issue:12 Volume:10 Page:5667-5677
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Chen Serena H.¹²³⁴,Kang Seung-gu¹²³⁴,Luo Judong⁵⁶⁷⁸⁹,Zhou Ruhong¹²³⁴¹⁰^ORCID

Affiliation:

1. Computational Biology Center

2. IBM Thomas J. Watson Research Center

3. Yorktown Heights

4. USA

5. Department of Oncology

6. The Affiliated Hospital of Nanjing Medical University

7. Changzhou No.2 People's Hospital

8. Changzhou

9. China

10. Department of Chemistry

Abstract

Unlike most matrix metalloproteinase (MMP) inhibitors, which target the conserved catalytic zinc site, Gd@C₈₂(OH)₂₂ indirectly inhibits MMP-9 activity by binding at the ligand specificity S1′ loop.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2018/NR/C8NR00127H

Reference42 articles.

1. C60: Buckminsterfullerene

2. Paramagnetic Water-Soluble Metallofullerenes Having the Highest Relaxivity for MRI Contrast Agents

3. Highly-Iodinated Fullerene as a Contrast Agent For X-ray Imaging

4. First Soluble M@C60 Derivatives Provide Enhanced Access to Metallofullerenes and Permit in Vivo Evaluation of Gd@C60[C(COOH)2]10 as a MRI Contrast Agent

5. R. F. Schinazi , R.Sijbesma , G.Srdanov , C. L.Hill and F.Wudl , Synthesis and Virucidal Activity of a Water-Soluble, Configurationally Stable, Derivatized C60 Fullerene , in Antimicrobial Agents and Chemotherapy , 1993 , vol. 37 , pp. 1707–1710

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