Synthesis and anti-tumor activity evaluation of salinomycin C20-O-alkyl/benzyl oxime derivatives-Reference-Cited by-同舟云学术

Synthesis and anti-tumor activity evaluation of salinomycin C20-O-alkyl/benzyl oxime derivatives

Published:2022 Issue:4 Volume:20 Page:870-876
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Li Bo¹^ORCID,Wu Jun²³⁴,Tang Lei⁵,Lian Xu¹,Li Zhongwen²³⁴,Duan Wenfang⁵,Qin Tong¹,Zhao Xintong¹,Hu Yuhua¹,Zhang Chi¹,Li Tianlei¹,Hao Jie²³⁴,Zhang Wenxuan¹^ORCID,Zhang Jihong⁵,Wu Song¹

Affiliation:

1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China

2. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

3. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China

4. National Stem Cell Resource Center, Chinese Academy of Sciences, Beijing 100101, China

5. Medical School of Kunming University of Science and Technology, Kunming, 650031, China

Abstract

Seventeen C20-O-alkyl/benzyl oxime derivatives were synthesized by a concise and effective method, which showed 15~240 folds better antiproliferative activity, more potent ion binding and transport ability and better selectivity indexes (SI) than salinomycin.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D1OB02292J

Reference40 articles.

1. Salinomycin, a new polyether antibiotic.

2. Biological Applications of Ionophores