Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry
Author:
Affiliation:
1. Institute of Integrative Biology
2. University of Liverpool
3. Liverpool, UK L69 7ZB
4. Faculty of Industrial Sciences and Technology
5. Universiti Malaysia Pahang
6. Centre for Molecular Oncology
7. Barts Cancer Institute
Abstract
A single maleimide was installed onto the self-assembled monolayer of gold nanoparticles by copper-free click chemistry. Simple covalent biofunctionalisation is demonstrated by coupling fibroblast growth factor 2 and an oligosaccharide in a 1 : 1 stoichiometry by thiol-Michael addition.
Funder
Medical Research Council
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2014/CC/C4CC05909C
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