Selective synthesis of pyridazine-fused chromones and 3-pyridazinyl chromones through intermolecular chromone annulation of <i>o</i>-hydroxyphenylenaminones with aryldiazonium salts-Reference-Cited by-同舟云学术

Selective synthesis of pyridazine-fused chromones and 3-pyridazinyl chromones through intermolecular chromone annulation of o-hydroxyphenylenaminones with aryldiazonium salts

Published:2024 Issue:14 Volume:11 Page:3906-3912
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Song Siyu¹,Zhang Zhilai¹,Peng Menglin¹,Xia Xueshan¹,Dong Shuwei¹,Wang Yongchao²,Yu Fuchao¹^ORCID

Affiliation:

1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650504, P. R. China

2. College of Vocational and Technical Education, Yunnan Normal University, Kunming, 650092, P.R. China

Abstract

A chemodivergent and skeleton-controllable annulation reactions of readily available o-HPEs and aryldiazonium salts was described for the synthesis of highly functionalized pyridazine-fused chromones with high antiviral activity and higher safety.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Yunnan Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO00677A

Reference41 articles.

1. Chromone: A Valid Scaffold in Medicinal Chemistry

2. Flavones: An important scaffold for medicinal chemistry

3. Chromones: A Promising Ring System for New Anti-inflammatory Drugs

4. Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances

5. Challenges with chromone as a privileged scaffold in drug discovery

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