Design, synthesis and biological evaluation of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4-diamines as antiplasmodial antifolates-Reference-Cited by-同舟云学术

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Design, synthesis and biological evaluation of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4-diamines as antiplasmodial antifolates

Published:2016 Issue:33 Volume:14 Page:7899-7911
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Lourens Anna C. U.¹²³⁴⁵,Gravestock David¹²³⁶⁷,van Zyl Robyn L.⁸⁹¹⁰¹¹¹²,Hoppe Heinrich C.¹²³¹³¹⁴,Kolesnikova Natasha¹²³,Taweechai Supannee¹⁵¹⁶¹⁷¹⁸,Yuthavong Yongyuth¹⁵¹⁶¹⁷¹⁸,Kamchonwongpaisan Sumalee¹⁵¹⁶¹⁷¹⁸,Rousseau Amanda L.¹²³¹⁹²⁰

Affiliation:

1. CSIR Biosciences

2. 0001 Gauteng

3. South Africa

4. Pharmaceutical Chemistry

5. School of Pharmacy

6. Syngenta

7. Jealott's Hill International Research Centre

8. Pharmacology Division

9. Department of Pharmacy and Pharmacology

10. WITS Research Institute for Malaria (WRIM)

11. Faculty of Health Sciences

12. University of the Witwatersrand

13. Department of Biochemistry and Microbiology

14. Rhodes University

15. BIOTEC

16. National Science and Technology Development Agency

17. Pathumthani 12120

18. Thailand

19. Molecular Sciences Institute

20. School of Chemistry

Abstract

One-pot multistep synthesis of 1,6-dihydro-1,3,5-triazines displaying potent antiplasmodial activity in vitro.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01350C

Reference27 articles.

1. WHO World Malaria Report 2015, accessed 1 March 2016, http://www.who.int/malaria/publications/world_malaria_report_2015/en/

2. Averting a malaria disaster: will insecticide resistance derail malaria control?

3. Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy

4. Exploring the folate pathway in Plasmodium falciparum

5. DNA and RNA Synthesis: Antifolates

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