Stereodivergent synthesis of 5-aminopipecolic acids and application in the preparation of a cyclic RGD peptidomimetic as a nanomolar αVβ3 integrin ligand-Reference-Cited by-同舟云学术

Stereodivergent synthesis of 5-aminopipecolic acids and application in the preparation of a cyclic RGD peptidomimetic as a nanomolar αVβ3 integrin ligand

Published:2018 Issue:18 Volume:16 Page:3402-3414
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Sernissi Lorenzo¹²³⁴^ORCID,Ricci Luciano¹²³⁴,Scarpi Dina¹²³⁴^ORCID,Bianchini Francesca⁵⁶⁷⁸⁴^ORCID,Arosio Daniela⁹¹⁰¹¹⁴^ORCID,Contini Alessandro¹²¹³¹⁴⁴^ORCID,Occhiato Ernesto G.¹²³⁴^ORCID

Affiliation:

1. Dipartimento di Chimica “U. Schiff”

2. Università degli Studi di Firenze

3. I-50019 Sesto Fiorentino

4. Italy

5. Department of Biomedical

6. Experimental and Clinical Sciences “Mario Serio”

7. University of Florence

8. Florence

9. Istituto di Scienze e Tecnologie Molecolari (I.S.T.M.)

10. Consiglio Nazionale delle Ricerche (C.N.R.)

11. I-20133 Milano

12. Dipartimento di Scienze Farmaceutiche

13. Università degli Studi di Milano

14. I-20133 Milan

Abstract

A stereodivergent preparation of trans and cis-5-aminopipecolic acids (5-APAs) was developed to obtain constrained amino acids useful for peptidomimetics.

Funder

Ministero dell'Istruzione, dell'Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00534F

Reference67 articles.

1. Emergence of Small-Molecule Non-RGD-Mimetic Inhibitors for RGD Integrins

2. Integrins

3. Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin

4. Structure and mechanics of integrin-based cell adhesion

5. Structural Basis of Integrin Regulation and Signaling

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