Direct observation of the oxidation of DNA bases by phosphate radicals formed under radiation: a model of the backbone-to-base hole transfer

Author:

Ma Jun1234,Marignier Jean-Louis1234,Pernot Pascal1234,Houée-Levin Chantal1234,Kumar Anil5678ORCID,Sevilla Michael D.5678ORCID,Adhikary Amitava5678ORCID,Mostafavi Mehran1234ORCID

Affiliation:

1. Laboratoire de Chimie Physique

2. CNRS/Université Paris-Sud 11

3. 91405 Orsay

4. France

5. Department of Chemistry

6. Oakland University

7. Rochester

8. USA

Abstract

In irradiated DNA, by the base-to-base and backbone-to-base hole transfer processes, the hole (i.e., the unpaired spin) localizes on the most electropositive base, guanine.

Funder

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Reference51 articles.

1. P. O’Neill , Radiation-Induced Damage in DNA . in Radiation Chemistry: Present Status and Future Trends , ed. B. S. M. Rao and C. D. Jonah , Elsevier Science , Amsterdam , 2001 , pp. 585–622

2. Radiation Chemistry: From Basics to Applications in Material and Life Sciences, Mehran Mostafavi, Thierry Douki, EDP Sciences, 2008

3. C. von Sonntag , Free-radical-induced DNA Damage and Its Repair , Springer-Verlag , Berlin, Heidelberg , 2006 , pp. 213–482

4. A. Adhikary , D.Becker and M. D.Sevilla , Electron Spin Resonance of Radicals in Irradiated DNA . in Applications of EPR in Radiation Research , ed. A. Lund and M. Shiotani , Springer International Publishing , Heidelberg, New York, London , 2014 , pp. 299–352

5. A. Kumar and M. D.Sevilla , Low Energy Electron (LEE) Induced DNA Damage: Theoretical Approaches to Modeling Experiment , in Handbook of Computational Chemistry Volume III: Applications–Biomolecules , ed. M. K. Shukla and J. Leszczynski , Springer-Verlag , Berlin, Heidelberg , 2012 , pp. 1215–1256

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