Disclosing biosynthetic connections and functions of atypical angucyclinones with a fragmented C-ring-Reference-Cited by-同舟云学术

Disclosing biosynthetic connections and functions of atypical angucyclinones with a fragmented C-ring

Published:2021 Issue:8 Volume:38 Page:1506-1517
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Mikhaylov Andrey A.¹²^ORCID,Ikonnikova Viktoria A.¹,Solyev Pavel N.³^ORCID

Affiliation:

1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow, 117997, Russia

2. National Research University Higher School of Economics, Faculty of Chemistry, 20 Myasnitskaya St., Moscow, 101000, Russia

3. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilova St., Moscow, 119991, Russia

Abstract

The phenomenon of angucyclinones resulting from angucycline C-ring fragmentation is analyzed in terms of generality, biosynthetic origin and plausible function.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NP/D0NP00082E

Reference74 articles.

1. Angucycline group antibiotics

2. Angucyclines: Total syntheses, new structures, and biosynthetic studies of an emerging new class of antibiotics

3. Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis

4. Structure and Function of a C–C Bond Cleaving Oxygenase in Atypical Angucycline Biosynthesis

5. The functional differentiation of the post-PKS tailoring oxygenases contributed to the chemical diversities of atypical angucyclines

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