Molecular dynamics investigations of membrane-bound CYP2C19 polymorphisms reveal distinct mechanisms for peripheral variants by long-range effects on the enzymatic activity-Reference-Cited by-同舟云学术

Molecular dynamics investigations of membrane-bound CYP2C19 polymorphisms reveal distinct mechanisms for peripheral variants by long-range effects on the enzymatic activity

Published:2017 Issue:6 Volume:13 Page:1070-1079
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Cui Ying-Lu¹²³⁴⁵^ORCID,Wu Rong-Ling¹²³⁴⁵^ORCID

Affiliation:

1. Center for Computational Biology

2. College of Biological Sciences and Biotechnology

3. Beijing Forestry University

4. Beijing

5. China

Abstract

The results reveal distinct mechanisms for enzymatic activity deficiencies upon two peripheral variants in CYP2C19.

Funder

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MB/C6MB00827E

Reference59 articles.

1. Advances in the Pharmacogenomics of Adverse Drug Reactions

2. Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges

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