Photoactivated cell-killing involving a low molecular weight, donor–acceptor diphenylacetylene-Reference-Cited by-同舟云学术

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Photoactivated cell-killing involving a low molecular weight, donor–acceptor diphenylacetylene

Published:2019 Issue:17 Volume:10 Page:4673-4683
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Chisholm David R.¹²³⁴⁵,Lamb Rebecca⁶²⁷⁵,Pallett Tommy⁶²⁷⁵⁸,Affleck Valerie⁹¹⁰¹¹⁵,Holden Claire¹²³⁴⁵,Marrison Joanne¹²¹³¹⁴¹⁵⁵,O'Toole Peter¹²¹³¹⁴¹⁵⁵,Ashton Peter D.¹²¹³¹⁴¹⁵⁵,Newling Katherine¹²¹³¹⁴¹⁵⁵,Steffen Andreas¹⁶¹⁷¹⁸¹⁹,Nelson Amanda K.¹⁶¹⁷¹⁸¹⁹,Mahler Christoph¹⁶¹⁷¹⁸¹⁹,Valentine Roy²⁰²¹²²⁵,Blacker Thomas S.²³²⁴²⁵⁵,Bain Angus J.²³²⁴²⁵⁵^ORCID,Girkin John⁸²⁶²²²⁵^ORCID,Marder Todd B.¹⁶¹⁷¹⁸¹⁹^ORCID,Whiting Andrew¹²³⁴⁵^ORCID,Ambler Carrie A.⁶²⁷⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Durham University

3. Science Laboratories

4. Durham DH1 3LE

5. UK

6. Department of Biosciences

7. Durham, DH1 3LE

8. Biophysical Sciences Institute

9. LightOx Limited

10. Wynyard Park House

11. Billingham

12. Bioscience Technology Facility

13. Department of Biology

14. University of York

15. York

16. Institut für Anorganische Chemie

17. Julius-Maximilians-Universität Würzburg

18. 97074 Würzburg

19. Germany

20. High Force Research Ltd.

21. Bowburn North Industrial Estate

22. Durham

23. Department of Physics & Astronomy

24. University College London

25. London

26. Department of Physics

Abstract

Drug-like, donor–acceptor diphenylacetylenes cause efficient cell death upon photoactivation and hence have potential phototherapeutic applications.

Funder

Biotechnology and Biological Sciences Research Council

Engineering and Physical Sciences Research Council

Julius-Maximilians-Universität Würzburg

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC00199A

Reference64 articles.

1. Cellular mechanisms and physiological consequences of redox-dependent signalling

2. Reactive oxygen species and the bacterial response to lethal stress

3. Photodynamic therapy for cancer

4. Mechanism of Photosensitized Generation of Singlet Oxygen during Oxygen Quenching of Triplet States and the General Dependence of the Rate Constants and Efficiencies of O2(1Σg+), O2(1Δg), and O2(3Σg-) Formation on Sensitizer Triplet State Energy and Oxidation Potential

5. Photosensitized Generation of Singlet Oxygen

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3. The antibacterial activity of a photoactivatable diarylacetylene against Gram-positive bacteria;Frontiers in Microbiology;2023-09-22

4. Solvent Polarity Governs Ultrafast Structural Dynamics: A Case Study of 4-Dimethylamino-4′-carbomethoxydiphenylacetylene;The Journal of Physical Chemistry C;2023-03-17

5. Bullseye Analysis: A Fluorescence Microscopy Technique to Detect Local Changes in Intracellular Reactive Oxygen Species (ROS) Production;Microscopy and Microanalysis;2022-12-22

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