Efflux pump inhibitor combined with ofloxacin decreases MRSA biofilm formation by regulating the gene expression of NorA and quorum sensing-Reference-Cited by-同舟云学术

Efflux pump inhibitor combined with ofloxacin decreases MRSA biofilm formation by regulating the gene expression of NorA and quorum sensing

Published:2023 Issue:4 Volume:13 Page:2707-2717
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Lu Xueer¹,Wang Guifeng²,Xie Yunfeng²,Tang Wenjian³^ORCID,Liu Biyong²,Zhang Jing²^ORCID

Affiliation:

1. Department of Clinical Laboratory, The Third People's Hospital of Hefei, Hefei, 230022, China

2. Anhui Prevention and Treatment Center for Occupational Disease, Anhui No. 2 Provincial People's Hospital, Hefei, 230041, China

3. School of Pharmacy, Anhui Medical University, Hefei 230032, China

Abstract

Carbonyl cyanide p-nitrophenylhydrazone (2e), an efflux pump inhibitor, displayed alone or synergistic efficacy against MRSA in vitro and in vivo through regulating the gene expression of NorA and QS system.

Funder

Natural Science Foundation of Anhui Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D2RA06696C

Reference38 articles.

1. Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis

2. Biofilm-Forming Methicillin-Resistant Staphylococcus aureus Survive in Kupffer Cells and Exhibit High Virulence in Mice

3. Antibiotic Tolerance of Staphylococcus aureus Biofilm in Periprosthetic Joint Infections and Antibiofilm Strategies

4. Biofilm propensity of Staphylococcus aureus skin isolates is associated with increased atopic dermatitis severity and barrier dysfunction in the MPAACH pediatric cohort

5. Design Guidelines for Cationic Pillar[n]arenes that Prevent Biofilm Formation by Gram-Positive Pathogens

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